Applications
Advance the Right Drug Candidates Across Modalities, At Scale
LumiPore® gives your discovery teams one scalable intracellular delivery platform for high-throughput biopharmaceutical library screening.
It replaces modality-specific delivery workflows with a gentle, laser-assisted photoporation system that works across proteins, peptides, antibodies, nanobodies, mRNA, DNA, and other biologically active cargos, from a single flask to 1536-well automated screens. The result is faster candidate progression, fewer workflow changes, and less re-optimization as programs scale.
The Challenge: More Candidates, More Modalities, More Complexity
Selecting the most promising drug candidates remains one of the central bottlenecks in modern drug discovery. Research teams increasingly work across a growing range of therapeutic formats, including proteins, peptides, antibodies, nanobodies, mRNA, DNA, and other biologically active molecules, each with its own delivery requirements and screening quirks.
As programs scale, this diversity compounds the problem. Different formats and experimental conditions typically demand different protocols, adding optimization effort and operational complexity just as teams need to evaluate more candidates, faster, within fixed project timelines.
The real challenge is not simply screening more candidates. It is keeping throughput high while preventing delivery workflows from becoming the bottleneck. LumiPore® helps you reduce format-specific complexity, keep assays moving, and advance promising candidates with greater confidence.
One Platform, Built for Flexibility and Scale
LumiPore® combines flexibility and scalability in one intracellular delivery platform. Instead of changing technologies for every therapeutic modality or screen format, researchers can use one consistent workflow across applications. That means faster setup, simpler execution, and fewer optimization cycles before useful data is generated.
At its core, LumiPore® uses a gentle, laser-assisted photoporation mechanism to deliver cargo directly in standard culture plates, preserving cell viability, functionality, and phenotype throughout the process.
Flexibility: One Platform, Every Modality
LumiPore® supports a broad range of cargo types, including proteins, peptides, antibodies, nanobodies, mRNA, plasmid DNA, CRISPR-Cas9 RNPs, siRNA, ASOs, and fluorescent tracers, across a broad range of cell types and screening formats.
The platform works with both adherent and suspension workflows and delivers directly into adherent cells without first detaching them. That removes an extra manipulation step that can introduce stress or variability, keeping results closer to native biology.
Scalability: From Bench to High-Throughput Screening
LumiPore® scales from traditional culture formats, including flasks and standard multi-well plates, to automation-ready screening in 384- and 1536-well formats without protocol redevelopment.
That range gives researchers the flexibility to scale cell numbers when larger populations are needed, or to scale experimental conditions when throughput is the priority. LumiPore® maintains consistent delivery performance and reproducibility across formats and is compatible with standard automation workflows.
How LumiPore® Works
High-throughput screening (HTS) is a cornerstone of modern drug discovery. It enables rapid evaluation of large numbers of compounds, conditions, or genetic perturbations for hit identification and target validation. Translating assays between formats, however, often requires extensive re-optimization, which adds cost, complexity, and variability.
LumiPore®’s gentle, laser-assisted photoporation mechanism enables efficient intracellular delivery directly in standard culture plates, preserving cell viability, functionality, and phenotype. It scales seamlessly from high-density formats like 1536-well plates up to larger culture vessels without protocol redevelopment, maintaining consistent delivery performance and reproducibility across the transition.
Applications
LumiPore®’s combination of broad cargo compatibility, format flexibility, and automation-readiness makes it suited to:
- HTS campaigns: hit identification and target validation across large candidate libraries
- Functional genomics: delivery of CRISPR-Cas9 RNPs, siRNA, and ASOs for gene function studies
- Cell engineering: efficient delivery of mRNA and plasmid DNA for engineered cell lines
- Therapeutic discovery: screening proteins, peptides, antibodies, and nanobodies as candidate biologics
Automation & Integration
LumiPore® is compatible with standard laboratory automation, supporting integration into automated HTS workflows.
Frequently Asked Questions
LumiPore® is a laser-assisted photoporation platform for intracellular delivery, used in high-throughput biopharmaceutical library screening across proteins, peptides, antibodies, nanobodies, mRNA, and DNA.
LumiPore® delivers proteins, peptides, antibodies, nanobodies, mRNA, plasmid DNA, CRISPR-Cas9 RNPs, siRNA, ASOs, and fluorescent tracers.
LumiPore® works across flasks and standard multi-well plates up to high-throughput, automation-ready 384- and 1536-well formats, without protocol redevelopment.
Yes. LumiPore® supports both adherent and suspension workflows, delivering directly into adherent cells without detachment.
Its combination of broad modality compatibility, scalability from bench to 1536-well plates, and automation readiness lets teams use one platform across screening programs instead of re-optimizing for each format.
High-Throughput Transfection.Automation-Ready.
Seamless integration into your existing robotics workflows. No media exchange required. From R&D suspensions to clinical nanofiber structures.