Highly Cited Researcher
We are excited to announce an important evolution in Trince’s leadership structure as we enter a new phase of accelerated growth and global expansion.
Advancing Cell Therapy: Photothermal nanofibers enable macromolecule delivery in unstimulated human T cells
We are excited to announce an important evolution in Trince’s leadership structure as we enter a new phase of accelerated growth and global expansion.
Key Findings: A Glimpse into the Future of T-Cell Modification.
Safety Assurance: Inductively coupled plasma tandem mass spectrometry confirms no significant iron release from PEN substrates at laser fluences up to 0.36 J/cm².
High Delivery Efficiency: Successful intracellular delivery of 150 kDa FITC-dextran attains a notable 55–60% efficiency in resting and pre-activated lymphocytes.
Minimal Impact on T Cell Properties: Rigorous analysis indicates no discernible effects on cell proliferation, activation propensity, and extracellular cytokine release.
Towards Genetic Modification: With these compelling outcomes, PEN photoporation emerges as a secure and efficient delivery strategy, setting the stage for its role in the genetic modification of minimally differentiated T cells.
Reach out to us if you would like to find out how we can help you advance your research.
Successful VLAIO R&D Grant Application!
The project runs until April 2025 and has three main objectives:
- Successful engineering of human T cells with large effector molecules (plasmids, mRNA and CRISPR/Cas9 RNPs) while preserving T cell fitness and therapeutic efficacy,
- Develop a prototype device for automated high-throughput transfection of T cells based on Trince’s proprietary photoporation technology and,
- Successful internal and external evaluation of the automated high-throughput prototype device.
Joint white paper with Revatis on delivering macromolecules into mesenchymal stem cells
We are excited to announce an important evolution in Trince’s leadership structure as we enter a new phase of accelerated growth and global expansion.
This exciting technology provides a gentler and more effective method of cell transfection and can be used on a variety of cell types!
82 citations one year after publication
We are excited to announce an important evolution in Trince’s leadership structure as we enter a new phase of accelerated growth and global expansion.
With 82 citations within one year after publication the paper has received the status of hot paper by Web of Science.
This means it is among the top 0.1% of the most cited papers in the field.
